Hamel F G, Solomon S S, Jespersen A S, Blotcky A, Rack E, Duckworth W C
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3020.
Metabolism. 1993 Dec;42(12):1503-5. doi: 10.1016/0026-0495(93)90142-b.
A great deal of interest in the element vanadium has been generated recently because of its potential as a therapeutic agent for diabetes mellitus. Vanadium's insulin-mimetic properties and its requirement for proper growth and development suggest that it may be involved in insulin's mechanism of action. We have therefore examined vanadium levels in kidney, muscle, and liver tissues from normal and diabetic BB Wistar rats. Our results indicate that diabetes mellitus can decrease the tissue vanadium content of liver, suggesting that the trace element vanadium may be important in insulin action.
由于钒元素具有作为糖尿病治疗剂的潜力，近来人们对它产生了极大的兴趣。钒的胰岛素模拟特性及其对正常生长发育的需求表明，它可能参与胰岛素的作用机制。因此，我们检测了正常和患糖尿病的BB系Wistar大鼠肾脏、肌肉及肝脏组织中的钒含量。我们的结果表明，糖尿病可降低肝脏组织中的钒含量，这表明微量元素钒在胰岛素作用中可能很重要。
