King M J, Pugazhenthi S, Khandelwal R L, Sharma R K
Saskatoon Cancer Centre, Canada.
Mol Cell Biochem. 1995;153(1-2):151-5. doi: 10.1007/BF01075931.
N-Myristoyltransferase (NMT) catalyses the transfer of myristate from myristoyl-CoA to the NH2-terminal glycine residue of several proteins and are important in signal transduction. STZ-induced diabetes (an animal model for insulin-dependent diabetes mellitus, IDDM) resulted in a 2-fold increase in rat liver NMT activity as compared with control animals. In obese Zucker (fa/fa) rats (an animal model for non-insulin dependent diabetes mellitus, NIDDM) there was a approximately 4.7-fold lower liver particulate NMT activity as compared with the control lean rat livers. Administration of sodium orthovanadate to the diabetic rats normalised liver NMT activity. These results would indicate that the rat liver particulate N-myristoyltransferase activity appears to be inversely proportional to the level of plasma insulin, implicating insulin in the control of N-myristoylation.
N-肉豆蔻酰基转移酶（NMT）催化肉豆蔻酸从肉豆蔻酰辅酶A转移至多种蛋白质的氨基末端甘氨酸残基，在信号转导中起重要作用。链脲佐菌素诱导的糖尿病（胰岛素依赖型糖尿病，IDDM的动物模型）导致大鼠肝脏NMT活性相比对照动物增加了2倍。在肥胖的Zucker（fa/fa）大鼠（非胰岛素依赖型糖尿病，NIDDM的动物模型）中，与对照瘦大鼠肝脏相比，肝脏微粒体NMT活性大约低4.7倍。给糖尿病大鼠施用原钒酸钠可使肝脏NMT活性恢复正常。这些结果表明，大鼠肝脏微粒体N-肉豆蔻酰基转移酶活性似乎与血浆胰岛素水平呈负相关，提示胰岛素参与N-肉豆蔻酰化的调控。
