Teff K L, Mattes R D, Engelman K, Mattern J
Monell Chemical Senses Center, Philadelphia 19104.
Metabolism. 1993 Dec;42(12):1600-8. doi: 10.1016/0026-0495(93)90157-j.
Cephalic-phase insulin release (CPIR) and its relation to postprandial insulin release were examined in 18 normal-weight and 15 obese men. When the insulin data were expressed as absolute differences from baseline values, obese subjects exhibited significantly greater CPIR than normal-weight subjects (normals, 8.7 +/- 2.1 microU/mL/10 min; obese, 13.4 +/- 4.3 microU/mL/10 min; P < .01). Obese subjects were then separated into groups depending on their fasting insulin levels. This showed that only those subjects with elevated fasting insulin levels exhibited greater CPIR than normal subjects, and suggested that previous reports of exaggerated CPIR in the obese are merely a reflection of a basal hypersecretion of insulin. However, when insulin values were expressed as percentages of baseline, no significant differences between normal-weight and obese subjects were found, although a trend toward an attenuated response was observed in the obese group as a whole (normals, 81.6 +/- 19.1 microU/mL/10 min; obese, 51.3 +/- 16.1 microU/mL/10 min). A significant correlation between cephalic-phase and postprandial insulin release was found in normal-weight subjects (r = .62, P < .05), but not in obese subjects (r = .02, P < .9).
在18名体重正常和15名肥胖男性中，研究了头期胰岛素释放（CPIR）及其与餐后胰岛素释放的关系。当胰岛素数据表示为与基线值的绝对差值时，肥胖受试者的CPIR显著高于体重正常的受试者（体重正常者，8.7±2.1微单位/毫升/10分钟；肥胖者，13.4±4.3微单位/毫升/10分钟；P<.01）。然后根据空腹胰岛素水平将肥胖受试者分组。结果显示，只有那些空腹胰岛素水平升高的受试者的CPIR高于正常受试者，这表明之前关于肥胖者CPIR夸大的报道仅仅反映了胰岛素的基础分泌过多。然而，当胰岛素值表示为基线的百分比时，体重正常和肥胖受试者之间未发现显著差异，尽管在整个肥胖组中观察到反应减弱的趋势（体重正常者，81.6±19.1微单位/毫升/10分钟；肥胖者，51.3±16.1微单位/毫升/10分钟）。在体重正常的受试者中，头期和餐后胰岛素释放之间存在显著相关性（r=.62，P<.05），但在肥胖受试者中未发现显著相关性（r=.02，P<.9）。
