Simon C, Schlienger J L, Sapin R, Imler M
Physiol Behav. 1986;36(3):465-9. doi: 10.1016/0031-9384(86)90316-1.
The existence of a preabsorptive insulin reflex is well known in animals but remains controversial in humans. Glycemia and insulin variations following olfactive and visual presentation of a standard meal were studied in 25 subjects, 10 of them (5 men and 5 women) of normal weight and 15 overweight (7 men and 8 women), after a 15 hour fast. Blood samples were collected continuously, every minute for 16 minutes after the meal was presented. The presentation produced an early blood insulin increment, variable in magnitude and time course and occurring between the 3rd and 9th minute, in both normal and overweight subjects. Glycemia variations were not significant. Our study demonstrated a positive correlation between the reflex insulin release, body weight and a conscious effort to maintain current body weight. However, the differences between overweight and normal subjects remained small. The physiological and psychological determinants of the cephalic phase of insulin secretion are discussed.
吸收前胰岛素反射在动物中已广为人知，但在人类中仍存在争议。在25名受试者中，研究了标准餐的嗅觉和视觉呈现后血糖和胰岛素的变化。其中10名（5名男性和5名女性）体重正常，15名超重（7名男性和8名女性），经过15小时禁食。在呈现餐后连续16分钟每分钟采集血样。在正常和超重受试者中，这种呈现均导致了早期血胰岛素升高，其幅度和时间过程各不相同，发生在第3至9分钟之间。血糖变化不显著。我们的研究表明，反射性胰岛素释放、体重与维持当前体重的自觉努力之间呈正相关。然而，超重与正常受试者之间的差异仍然很小。本文讨论了胰岛素分泌头期的生理和心理决定因素。
