Pompei R, Ingianni A, Cagetti M G, Rizzo A, Cotti S
Istituto di Microbiologia, Università di Cagliari, Italy.
Microbios. 1993;75(304):149-57.
The occurrence of opportunistic pathogens and the concentration of some antimicrobial factors in the oral cavity of both acute and chronic leukaemia patients were studied. Enterobacteria were isolated from both dental plaque and crevicular fluid of all the groups examined, with few differences between healthy volunteers and leukaemic subjects; yeasts were found in both the crevicular fluid and the dental plaque samples of chronic leukaemia patients, but only in the plaque of healthy volunteers. Acute leukaemia patients did not have yeasts, but they were the only group colonized by the pseudomonads. IgA and N-acetyl-D-glucosaminidase (NAGase) significantly increased in chronic leukaemia patients compared with controls, whilst lysozyme seemed to present no marked differences for all groups. A further increase in NAGase concentration and an elevation in lysozyme content of saliva was observed for chronic leukaemia patients with severe periodontal lesions.
对急性和慢性白血病患者口腔中机会性病原体的出现情况以及一些抗菌因子的浓度进行了研究。在所有检查组的牙菌斑和龈沟液中均分离出肠杆菌，健康志愿者和白血病患者之间差异不大；在慢性白血病患者的龈沟液和牙菌斑样本中均发现了酵母菌，但仅在健康志愿者的牙菌斑中发现。急性白血病患者没有酵母菌，但他们是唯一被假单胞菌定植的组。与对照组相比，慢性白血病患者的IgA和N - 乙酰 - D - 氨基葡萄糖苷酶（NAGase）显著增加，而所有组的溶菌酶似乎没有明显差异。对于患有严重牙周病变的慢性白血病患者，观察到NAGase浓度进一步增加，唾液中溶菌酶含量升高。
