Chao F C, Green D E, Forrest I S, Kaplan J N, Winship-Ball A, Braude M
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):303-17.
Lactating squirrel monkeys chronically receiving 2 mg/kg delta-9-tetrahydrocannabinol (THC) orally either two or five times weekly were given a tracer dose of 14C-delta-9-THC mixed with the delta-9-THC. This permitted radioquantitation of the THC in milk specimens collected 1 to 24 hr after administration of the labeled dose. Correlated specimens of urine and feces were also collected individually from mothers and infants and were subjected to radioquantitation and exploratory TLC. During the 24-hr observation period, approximately 0.2% of the labeled delta-9-THC appeared in the milk, whereas 42% and 1% were excreted in the feces and urine, respectively. Infants that suckled during the 6 hr immediately after their mothers were administered the labeled compound excreted an average of 0.01% and 0.12% of the mother's dose in the urine and feces, respectively, during the 18 hr after suckling.
长期每周口服两次或五次2毫克/千克δ-9-四氢大麻酚（THC）的哺乳期松鼠猴，被给予与δ-9-THC混合的示踪剂量14C-δ-9-THC。这使得能够对给予标记剂量后1至24小时收集的乳汁样本中的THC进行放射性定量。还分别从母亲和婴儿个体收集尿液和粪便的相关样本，并进行放射性定量和探索性薄层层析。在24小时观察期内，约0.2%的标记δ-9-THC出现在乳汁中，而分别有42%和1%经粪便和尿液排出。在母亲给予标记化合物后立即哺乳的婴儿，在哺乳后18小时内，尿液和粪便中分别平均排出母亲剂量的0.01%和0.12%。
