Cronin-Golomb A, Sugiura R, Corkin S, Growdon J H
Department of Psychology, Boston University, MA 02215.
Neurobiol Aging. 1993 Sep-Oct;14(5):471-7. doi: 10.1016/0197-4580(93)90105-k.
We report that patients with Alzheimer's disease (AD) have a selective deficit in blue hue discrimination, as assessed with three clinical measures of color vision. The Farnsworth D-15 Test, the Lanthony New Color Test, and the City University Color Vision Test were administered to 32 patients with AD (ranging in dementia severity from mild to severe) and 32 age-matched normal control subjects (NCS). Of the AD patients, 11 who were representative of the larger group for age, education level, and dementia severity received a complete neuro-ophthalmological examination that ruled out obvious disorders of the anterior visual structures. AD patients made significantly more tritan (blue) errors than NCS on all three color vision tests but did not make more protan (red) or deutan (green) errors on two of the three tests. The results support the conclusion that there is a deficit in color discrimination in AD that is specific to blue hues, and oppose the hypothesis that AD does not deleteriously affect the color-opponent visual channel. In the absence of obvious damage to anterior visual structures, the likely substrates for the observed deficit are peristriate and inferotemporal visual cortices, which are subject to significant neuropathology in AD.
我们报告称，通过三种色觉临床测量方法评估发现，阿尔茨海默病（AD）患者在蓝色色调辨别方面存在选择性缺陷。对32例AD患者（痴呆严重程度从轻度到重度）和32名年龄匹配的正常对照受试者（NCS）进行了法恩斯沃思D - 15测试、兰托尼新颜色测试和城市大学色觉测试。在AD患者中，11名在年龄、教育水平和痴呆严重程度方面代表了较大群体的患者接受了全面的神经眼科检查，排除了前部视觉结构的明显疾病。在所有三项色觉测试中，AD患者的蓝色（三原色）错误明显多于NCS，但在三项测试中的两项中，红色（红色盲）或绿色（绿色盲）错误并未增多。结果支持这样的结论，即AD患者存在特定于蓝色色调的颜色辨别缺陷，这与AD不会对颜色对立视觉通道产生有害影响的假设相悖。在没有前部视觉结构明显损伤的情况下，观察到的缺陷的可能基础是纹周和颞下视觉皮层，这些区域在AD中会出现明显的神经病理学变化。
