烟雾病（大脑 Willis 环自发性闭塞）患者的脑脊液中含有高水平的碱性成纤维细胞生长因子。
The cerebrospinal fluid in patients with moyamoya disease (spontaneous occlusion of the circle of Willis) contains high level of basic fibroblast growth factor.
作者信息
Takahashi A, Sawamura Y, Houkin K, Kamiyama H, Abe H
机构信息
Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
出版信息
Neurosci Lett. 1993 Oct 1;160(2):214-6. doi: 10.1016/0304-3940(93)90416-i.
The level of basic fibroblast growth factor (bFGF) in cerebrospinal fluid (CF) was measured by an EIA in 15 patients with moyamoya disease, in 11 patients with atherosclerotic occlusive disease, and in 8 patients with spinal disc disease. In the moyamoya patients, bFGF was found in 13 out of 15 CF samples with a mean value of 101 pg/ml. However, bFGF was detected in only 4 out of 11 patients with atherosclerotic disease with a mean of 8 pg/ml. In all the patients with disc disease, bFGF was not detected. The elevated level of bFGF may play a crucial role in the pathogenesis of moyamoya disease.
采用酶免疫分析法（EIA）检测了15例烟雾病患者、11例动脉粥样硬化闭塞性疾病患者和8例椎间盘疾病患者脑脊液（CF）中碱性成纤维细胞生长因子（bFGF）的水平。在烟雾病患者中，15份CF样本中有13份检测到bFGF，平均值为101 pg/ml。然而，在11例动脉粥样硬化疾病患者中，仅4例检测到bFGF，平均值为8 pg/ml。在所有椎间盘疾病患者中，均未检测到bFGF。bFGF水平升高可能在烟雾病发病机制中起关键作用。
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