GM-CSF 促进烟雾病中功能失调的血管网络的发展。
GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease.
机构信息
Department of Neurology and Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Department of Neurology and Neurosurgery, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China.
出版信息
Neurosci Bull. 2024 Apr;40(4):451-465. doi: 10.1007/s12264-023-01158-y. Epub 2023 Dec 19.
Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels. Immune inflammation is associated with the occurrence and development of MMD. However, the mechanisms underlying the formation of the abnormal vascular network remain unclear. Twenty-eight patients with MMD, 26 ischemic stroke patients, and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) were higher in MMD patients than in healthy controls (P <0.01), and GM-CSF was mainly from Th1 and Th17 cells in MMD. We found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis, inflammation, and chemotaxis. In summary, our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.
烟雾病（MMD）是一种慢性闭塞性脑血管病，其特征为异常血管网的形成。免疫炎症与 MMD 的发生和发展有关。然而，异常血管网形成的机制尚不清楚。本研究纳入了 28 例 MMD 患者、26 例缺血性脑卒中患者和 26 名无关的健康志愿者。结果显示，MMD 患者的粒细胞-巨噬细胞集落刺激因子（GM-CSF）水平高于健康对照组（P<0.01），MMD 患者的 GM-CSF 主要来自 Th1 和 Th17 细胞。我们发现，升高的 GM-CSF 驱动单核细胞分泌一系列与血管生成、炎症和趋化有关的细胞因子。综上所述，本研究首次证明了 GM-CSF 在 MMD 中的重要作用，提示 GM-CSF 是 MMD 异常血管网形成的一个重要因素。
Zotero 插件