Mehra I V, Wilson M D
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, Pennsylvania.
Pharmacotherapy. 1993 Sep-Oct;13(5):440-6.
During and immediately after myocardial infarction (MI), many interrelated and complex processes manifest the body's attempt to minimize damage and compensate for lost cardiac function. Although these compensatory responses may provide some short-term restoration of function, their long-term consequences actually may increase morbidity and mortality. Several agents have established roles in the treatment of these patients, whereas others, including the angiotensin-converting enzyme (ACE) inhibitors, have yet to be investigated thoroughly. Results of two trials investigating the role of ACE inhibition after MI seem to provide sufficient data to warrant the use of these drugs in certain patient populations. These results are promising, but further investigation is necessary to answer key questions arising from these trials.
在心肌梗死（MI）期间及刚发生后，许多相互关联且复杂的过程体现了机体将损伤降至最低并代偿丧失的心功能的努力。尽管这些代偿反应可能会使功能得到一些短期恢复，但其长期后果实际上可能会增加发病率和死亡率。几种药物在治疗这些患者方面已确立了作用，而其他一些药物，包括血管紧张素转换酶（ACE）抑制剂，尚未得到充分研究。两项探究ACE抑制在MI后作用的试验结果似乎提供了足够的数据，证明在某些患者群体中使用这些药物是合理的。这些结果很有前景，但仍需进一步研究以回答这些试验中出现的关键问题。
