Hytiroglou P, Strauchen J A, Vrettou E, Papadimitriou C S, Fasy T M, Morgello S
Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029.
Mod Pathol. 1993 Sep;6(5):575-80.
Seven cases of primary lung lymphoma were analyzed for the presence of Epstein-Barr virus DNA sequences by the polymerase chain reaction. The series included: four cases of diffuse, small lymphocytic lymphoma; one case of diffuse, intermediate lymphocytic lymphoma; one case of diffuse, small cleaved cell lymphoma; and one case of large cell, immunoblastic lymphoma. The latter occurred in a patient with acquired immunodeficiency syndrome. A 200-bp sequence of the Epstein-Barr nuclear antigen 1 gene was used as a template for PCR amplification. The only tumor that contained Epstein-Barr virus sequences was the immunoblastic lymphoma. These findings support previous observations that small lymphocytic lymphomas of the lung are not related to Epstein-Barr virus infection. In contrast, some large cell lymphomas may represent Epstein-Barr-virus--associated lymphoproliferative disorders.
通过聚合酶链反应分析了7例原发性肺淋巴瘤中Epstein-Barr病毒DNA序列的存在情况。该系列包括：4例弥漫性小淋巴细胞淋巴瘤；1例弥漫性中等淋巴细胞淋巴瘤；1例弥漫性小裂细胞淋巴瘤；以及1例大细胞免疫母细胞淋巴瘤。后者发生在一名获得性免疫缺陷综合征患者身上。Epstein-Barr核抗原1基因的一段200bp序列被用作PCR扩增的模板。唯一含有Epstein-Barr病毒序列的肿瘤是免疫母细胞淋巴瘤。这些发现支持了先前的观察结果，即肺小淋巴细胞淋巴瘤与Epstein-Barr病毒感染无关。相比之下，一些大细胞淋巴瘤可能代表Epstein-Barr病毒相关的淋巴增殖性疾病。
