对世代时间对分子进化影响的考察。
An examination of the generation-time effect on molecular evolution.
作者信息
Ohta T
机构信息
National Institute of Genetics, Mishima, Japan.
出版信息
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10676-80. doi: 10.1073/pnas.90.22.10676.
Abstract
By using DNA sequences of 17 mammalian genes, the generation-time effect is estimated separately for synonymous substitutions and nonsynonymous substitutions. Star phylogenies composed of rodentia, artiodactyla, and primates are examined. The generation-time effect is found to be more conspicuous for synonymous substitutions than for non-synonymous substitutions, by using the methods of (i) Nei and Gojobori, (ii) Li, and (iii) Ina. The proportion of accepted amino acid substitutions in evolution is estimated to be about twice as large in the primate lineage as in the rodent lineage. This result is in accord with the nearly neutral theory of molecular evolution.
摘要
通过使用17种哺乳动物基因的DNA序列，分别针对同义替换和非同义替换估算世代时间效应。研究了由啮齿目、偶蹄目和灵长目组成的星状系统发育树。通过（i）Nei和Gojobori的方法、（ii）Li的方法以及（iii）Ina的方法发现，同义替换的世代时间效应比非同义替换更为显著。进化过程中被接受的氨基酸替换比例在灵长目谱系中估计约为啮齿目谱系中的两倍。这一结果与分子进化的近中性理论相符。
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