RNA enzyme-directed gene therapy.
作者信息
Altman S
机构信息
Department of Biology, Yale University, New Haven, CT 06520.
出版信息
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10898-900. doi: 10.1073/pnas.90.23.10898.
Abstract
摘要
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Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10898-900. doi: 10.1073/pnas.90.23.10898.
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Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.通过表达反义胰岛素样生长因子I RNA的免疫原性C6细胞治疗和预防大鼠胶质母细胞瘤
Science. 1993 Jan 1;259(5091):94-7. doi: 10.1126/science.8418502.
2
A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1.一种发夹状核酶可抑制多种1型人类免疫缺陷病毒毒株的表达。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6340-4. doi: 10.1073/pnas.90.13.6340.
3
Importance of independence in ribozyme reactions: kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against human immunodeficiency virus.核酶反应中独立性的重要性：截短型及具有抗人类免疫缺陷病毒潜在活性的简单连接多聚核酶的动力学行为
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11302-6. doi: 10.1073/pnas.90.23.11302.
4
Ribozyme cleaves rex/tax mRNA and inhibits bovine leukemia virus expression.核酶切割rex/tax信使核糖核酸并抑制牛白血病病毒的表达。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10932-6. doi: 10.1073/pnas.90.23.10932.
5
Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site.拟议中的55个核苷酸活性位点负责病毒类RNA的自我切割。
Cell. 1987 Jul 3;50(1):9-16. doi: 10.1016/0092-8674(87)90657-x.
6
Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes.嗜热四膜虫核酶的序列特异性核糖核酸内切酶活性：形成错配核酶-底物复合物的某些寡核苷酸底物的切割增强。
Biochemistry. 1988 Dec 13;27(25):8924-31. doi: 10.1021/bi00425a008.
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A small catalytic oligoribonucleotide.一种小型催化性寡核糖核苷酸。
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Nucleic Acids Res. 1990 Jan 25;18(2):299-304. doi: 10.1093/nar/18.2.299.
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10
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Proc Natl Acad Sci U S A. 1991 May 15;88(10):4313-7. doi: 10.1073/pnas.88.10.4313.
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