白细胞介素10的一种受体与干扰素受体相关。
A receptor for interleukin 10 is related to interferon receptors.
作者信息
Ho A S, Liu Y, Khan T A, Hsu D H, Bazan J F, Moore K W
机构信息
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
出版信息
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71. doi: 10.1073/pnas.90.23.11267.
We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (approximately 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways.
我们从小鼠肥大细胞和巨噬细胞系中分离出编码小鼠白细胞介素10受体（mIL-10R）的cDNA。这两个cDNA基本相同，并在COS7细胞中表达一种约110 kDa的多肽，该多肽能特异性结合mIL-10。表达转染重组mIL-10R的小鼠前B细胞系（Ba/F3）以高亲和力（约70 pM）结合IL-10，并在mIL-10刺激下增殖。mIL-10R在结构上与干扰素受体（IFNRs）相关。由于IL-10可抑制IFN-γ介导的巨噬细胞活化，因此这种关系可能意味着IL-10R与IFN-γR之间存在相互作用或它们的信号通路存在相互作用。
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