Chung D S, Benedek G B, Konikoff F M, Donovan J M
Department of Physics, Massachusetts Institute of Technology, Cambridge 02139.
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11341-5. doi: 10.1073/pnas.90.23.11341.
We report measurements of the geometrical structure and temporal evolution of metastable helical intermediates in the pathway for cholesterol crystallization in native and model biles. We find that the lecithin component in the bile can dramatically affect the kinetics along this pathway. We also present a theoretical description of these helical intermediates using an elastic free energy appropriate for anisotropic bilayers of tilted chiral amphiphiles, which provides a quantitative description of the observed helical ribbon geometry and insight into the relative free energies of the observed metastable intermediates.
我们报告了天然胆汁和模拟胆汁中胆固醇结晶途径中亚稳螺旋中间体的几何结构和时间演变的测量结果。我们发现胆汁中的卵磷脂成分可显著影响该途径的动力学。我们还使用适用于倾斜手性两亲物各向异性双层的弹性自由能，对这些螺旋中间体进行了理论描述，这为观察到的螺旋带几何结构提供了定量描述，并深入了解了观察到的亚稳中间体的相对自由能。
