Fabra A, Giordano W, Rivarola V, Mori G, Castro S, Balegno H
Facultad de Ciencias Exactas, Universidad Nacional de Rio Cuarto, Córdoba, Argentina.
Toxicology. 1993 Oct 25;83(1-3):19-29. doi: 10.1016/0300-483x(93)90088-a.
2,4-Dichlorophenoxyacetic acid (2,4-D) is an herbicide used extensively in agriculture. We had previously determined that 1 mM 2,4-D could inhibit cell growth, DNA and protein synthesis of Azospirillum brasilense. The present work was designed to determine if these alterations are a consequence of 2,4-D action on polyamine biosynthesis and if the protein synthesis inhibition is a result of ribosomal impairment. In this paper we demonstrate that 2,4-D alters the metabolism of polyamines and, thus, affects protein synthesis at the ribosomal level.
