2,4-二氯苯氧乙酸对多胺生物合成的影响。

2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.

作者信息

Rivarola V, Balegno H

机构信息

Departamento Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Córdoba, Argentina.

出版信息

Toxicology. 1991;68(2):109-19. doi: 10.1016/0300-483x(91)90014-r.

DOI:10.1016/0300-483x(91)90014-r

PMID:1891779

Abstract

2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide extensively used in agriculture. It was considered of interest to study its toxicity on animal cells. We had previously determined that 1 mM 2,4-D can inhibit cell growth, DNA and protein synthesis of cultured Chinese hamster ovary cells (CHO) with cell accumulation in the G1/S interphase of the cell cycle. The present work examined the effects of 2,4-D on polyamine biosynthesis. The results suggest some possible mechanism of the herbicide's toxic effects on animal cells.

摘要

2,4-二氯苯氧乙酸（2,4-D）是一种在农业中广泛使用的除草剂。研究其对动物细胞的毒性具有重要意义。我们之前已经确定，1 mM的2,4-D能够抑制培养的中国仓鼠卵巢细胞（CHO）的细胞生长、DNA和蛋白质合成，并使细胞在细胞周期的G1/S间期积累。本研究考察了2,4-D对多胺生物合成的影响。结果提示了该除草剂对动物细胞产生毒性作用的一些可能机制。