Ilett K F, Blythe T H, Hackett L P, Ong R T, Tannenbaum D A, Clarke T M
Combined Unit in Clinical Pharmacology and Toxicology, University of Western Australia/State Health Laboratory Services, Nedlands.
Ther Drug Monit. 1993 Oct;15(5):351-7. doi: 10.1097/00007691-199310000-00001.
Plasma concentration-antidepressant response relationships for dothiepin, nordothiepin, dothiepin-S-oxide, and nordothiepin-S-oxide were investigated in 50 patients (33 women and 17 men), who had had a major depressive episode. Depression and anxiety were assessed at the start of therapy and after 2 and 4 weeks by measurement of a Hamilton rating score for depression (HRSD), a Beck depression inventory (BECK), visual analog scores for depression (VASDEP) and anxiety (VASANX), and a physician's global (GLOBAL) score. There were significant (p < 0.001) decreases in both mean depression (32-69%) and mean anxiety (30-44%) scores at weeks 2 and 4, but there were no robust linear or polynomial correlations between percent decrease in depression or anxiety scores and plasma concentrations of dothiepin or its metabolites at week 4. It is suggested that measurement of the nordothiepin/dothiepin ratio may assist in the assessment of compliance.
对50例（33例女性和17例男性）曾患重度抑郁发作的患者，研究了多塞平、去甲多塞平、多塞平-S-氧化物和去甲多塞平-S-氧化物的血药浓度-抗抑郁反应关系。在治疗开始时以及治疗2周和4周后，通过测量汉密尔顿抑郁评定量表（HRSD）评分、贝克抑郁量表（BECK）、抑郁视觉模拟评分（VASDEP）和焦虑视觉模拟评分（VASANX）以及医生整体评分（GLOBAL），对抑郁和焦虑进行评估。在第2周和第4周时，平均抑郁评分（降低32 - 69%）和平均焦虑评分（降低30 - 44%）均有显著下降（p < 0.001），但在第4周时，抑郁或焦虑评分的降低百分比与多塞平及其代谢产物的血药浓度之间不存在显著的线性或多项式相关性。研究表明，测量去甲多塞平/多塞平比值可能有助于评估依从性。
