Convit J, Ulrich M, Fernández C T, Tapia F J, Cáceres-Dittmar G, Castés M, Rondón A J
Instituto de Biomedicina, Caracas, Venezuela.
Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):444-8. doi: 10.1016/0035-9203(93)90030-t.
American cutaneous leishmaniasis is characterized by a spectrum of clinical manifestations. These include localized, often self-healing single lesions, intermediate forms which frequently produce mucosal lesions and often show exaggerated delayed-type hypersensitivity (DTH), and the rare diffuse cutaneous leishmaniasis in which no reaction of protective cell-mediated immunity or DTH can be demonstrated. Clinical, pathological and immunological studies have begun to unravel some of the mechanisms associated with different disease manifestations, dependent on complex interactions between the host immune response, measured in terms of indices including lymphocyte subsets and lymphokines in vitro and within active lesions, and different species of Leishmania.
美洲皮肤利什曼病具有一系列临床表现。这些表现包括局限性的、通常可自愈的单个皮损；中间型，常出现黏膜损害，且常表现出过度的迟发型超敏反应（DTH）；以及罕见的弥漫性皮肤利什曼病，在这种类型中无法证明存在保护性细胞介导免疫反应或DTH。临床、病理和免疫学研究已开始揭示与不同疾病表现相关的一些机制，这些机制取决于宿主免疫反应（通过包括体外及活动性皮损内的淋巴细胞亚群和淋巴因子等指标来衡量）与不同种类利什曼原虫之间的复杂相互作用。
