美国皮肤利什曼病患者皮肤病变中诱导型一氧化氮合酶的表达。
Expression of inducible nitric oxide synthase in skin lesions of patients with american cutaneous leishmaniasis.
作者信息
Qadoumi Muna, Becker Inge, Donhauser Norbert, Röllinghoff Martin, Bogdan Christian
机构信息
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany.
出版信息
Infect Immun. 2002 Aug;70(8):4638-42. doi: 10.1128/IAI.70.8.4638-4642.2002.
Abstract
Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast, little is known about the expression and function of iNOS in human leishmaniasis. Here, we show by immunohistological analysis of skin biopsies from Mexican patients with local (LCL) or diffuse (DCL) cutaneous leishmaniasis that the expression of iNOS was most prominent in LCL lesions with small numbers of parasites whereas lesions with a high parasite burden (LCL or DCL) contained considerably fewer iNOS-positive cells. This is the first study to suggest an antileishmanial function of iNOS in human Leishmania infections in vivo.
摘要
细胞因子诱导型（或2型）一氧化氮合酶（iNOS）对于小鼠体内杜氏利什曼原虫或硕大利什曼原虫感染的消退至关重要。相比之下，关于iNOS在人类利什曼病中的表达和功能却知之甚少。在此，我们通过对墨西哥局部（LCL）或弥漫性（DCL）皮肤利什曼病患者的皮肤活检组织进行免疫组织学分析表明，iNOS的表达在寄生虫数量较少的LCL病变中最为显著，而寄生虫负荷高的病变（LCL或DCL）中iNOS阳性细胞则少得多。这是第一项提示iNOS在人类利什曼原虫体内感染中具有抗利什曼原虫功能的研究。
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