Logan A, Berry M
Department of Clinical Chemistry, University of Birmingham, Edgbaston, UK.
Trends Pharmacol Sci. 1993 Sep;14(9):337-42. doi: 10.1016/0165-6147(93)90007-7.
After injuries that penetrate the mature brain or spinal cord, damaged axons initially show a growth response, but later their regeneration is aborted as a dense permanent scar is laid down within the core of the wound. Functional recovery from such injuries is poor and morbidity is severe, particularly for those patients with spinal cord damage. Clinically, no long term therapeutic treatments have been developed that might inhibit scarring and promote neuronal growth. Consequently, the prevalence of patients permanently disabled from head and spinal cord injury is high, estimated at more than 1:1000 of the population of North America (Office of Technology Assessment USA, 1990). Ann Logan and Martin Berry define the mechanisms that underlie the wound healing response in the CNS and discuss the rationale for the development of novel therapeutic strategies.
在穿透成熟脑或脊髓的损伤后，受损轴突最初会表现出生长反应，但随后其再生会中止，因为在伤口核心部位会形成致密的永久性瘢痕。此类损伤后的功能恢复很差，发病率很高，尤其是对于脊髓损伤患者。临床上，尚未开发出可能抑制瘢痕形成并促进神经元生长的长期治疗方法。因此，因头部和脊髓损伤而永久致残的患者患病率很高，据估计在北美人口中超过千分之一（美国技术评估办公室，1990年）。安·洛根和马丁·贝里阐述了中枢神经系统伤口愈合反应的潜在机制，并讨论了开发新型治疗策略的基本原理。
