Przybyłowski J, Bartelik S, Szrajer J, Kolus D
Kliniki Chorób Wewnetrznych Instytutu Medycyny Klinicznej, Kielcach.
Wiad Lek. 1993 Jan-Feb;46(1-2):9-13.
In 25 patients with duodenal ulcer, before treatment and after three weeks, and another 30 days of treatment with ranitidine, plasma concentrations were determined of IgA, IgG, IgM immunoglobulins, and of 10 other proteins. In comparison to the control group of 20 persons, a statistically significant decrease was found in the concentration of alpha 2-M, prealbumins, and IgG, as well as a significant increase of alpha 1-AT, C4 complement component, and a non-significant increase of coeruloplasmin, haptoglobin and IgM. During the treatment a tendency was observed for an increase of IgG and IgM level, as well as a statistically significant decrease of alpha 1-AT, C4, and coeruloplasmin concentration. The treatment exerted no effect on the decreased level of alpha 2-M. It was accepted that the tendency for an increase of IgG and IgM level was due, most probably, to the immunostimulating action of ranitidine, and the changes of concentrations of other parameters induced by the treatment were related to the presence and healing of the ulceration. The observed decrease of alpha 2-M level was probably due to binding of alpha 2-M to pepsinogen whose blood level was increased during gastric ulcer.
对25例十二指肠溃疡患者在治疗前、治疗3周后以及再用雷尼替丁治疗30天后，测定了血浆中IgA、IgG、IgM免疫球蛋白以及其他10种蛋白质的浓度。与20人的对照组相比，发现α2 -M、前白蛋白和IgG的浓度有统计学意义的下降，以及α1 -抗胰蛋白酶、C4补体成分有显著升高，血浆铜蓝蛋白、触珠蛋白和IgM有非显著性升高。在治疗期间，观察到IgG和IgM水平有升高的趋势，以及α1 -抗胰蛋白酶、C4和血浆铜蓝蛋白浓度有统计学意义的下降。治疗对α2 -M降低的水平没有影响。认为IgG和IgM水平升高的趋势很可能是由于雷尼替丁的免疫刺激作用，而治疗引起的其他参数浓度变化与溃疡的存在和愈合有关。观察到的α2 -M水平降低可能是由于α2 -M与胃蛋白酶原结合，而胃溃疡期间胃蛋白酶原的血水平升高。
