人α2-巨球蛋白及其在血清和血浆中的抗胰蛋白酶和抗凝血酶活性。

Human alpha2-macroglobulin and its antitrypsic and antithrombin activities in serum and plasma.

作者信息

de Vonne T L, Mouray H

出版信息

Clin Chim Acta. 1978 Nov 15;90(1):83-5. doi: 10.1016/0009-8981(78)90087-6.

Abstract

alpha2-Macroglobulin level, trypsin protein esterase and progressive antithrombin activities were measured in normal and nephrotic sera and plasma. Trypsin protein esterase activity was proportional to the alpha2-macroglobulin concentration in serum and plasma from both normal and nephrotic patients. The results were different, however, with progressive antithrombin activity: in normal plasma, antithrombin III is the main thrombin inhibitor, then alpha2-macroglobulin and alpha1-antitrypsin, whereas in nephrotic syndrome patients, alpha2-macroglobulin is the main thrombin inhibitor.

摘要

在正常和肾病血清及血浆中检测了α2-巨球蛋白水平、胰蛋白酶蛋白酯酶活性和进行性抗凝血酶活性。正常和肾病患者的血清及血浆中，胰蛋白酶蛋白酯酶活性与α2-巨球蛋白浓度成正比。然而，进行性抗凝血酶活性的结果有所不同：在正常血浆中，抗凝血酶III是主要的凝血酶抑制剂，其次是α2-巨球蛋白和α1-抗胰蛋白酶，而在肾病综合征患者中，α2-巨球蛋白是主要的凝血酶抑制剂。