Herse P, Akakura N, Ooi C
Department of Optometry, University of Auckland, New Zealand.
Acta Ophthalmol (Copenh). 1993 Aug;71(4):539-43. doi: 10.1111/j.1755-3768.1993.tb04632.x.
Measurement of the topographical corneal edema response has been previously restricted by the use of optical pachometry and small sample sizes. This study uses ultrasound pachometry to measure changes in the corneal thickness of 23 subjects at 9 locations during 2 hours' wear of a thick soft contact lens. The data are analysed using both averaged and individual location data. The averaged location analysis supports the current paradigm that less edema occurs in the peripheral cornea than in the central cornea during contact lens wear. However, the individual location analysis reveals a more complex corneal edema response in which the greatest amount of edema following 2 hours' contact lens wear occurred in the central and mid-peripheral temporal cornea, in comparison with the peripheral nasal and peripheral inferior cornea which showed the least edema. The edema measured in the peripheral temporal and peripheral superior cornea following 2 hours' contact lens wear was not significantly different from that measured in the central cornea. The edema measured in the central cornea following 2 hours' contact lens wear was not significantly different from that found at any mid-peripheral location. This study demonstrates that the corneal edema response associated with 2 hours' wear of a thick soft contact lens is a complex dynamic topographical process and cannot be simply modelled using averaged data from small samples.
以往，地形学角膜水肿反应的测量受光学测厚法和小样本量的限制。本研究采用超声测厚法，在23名受试者佩戴厚软性接触镜2小时期间，测量其角膜9个位置的厚度变化。数据分析采用平均位置数据和各个位置的数据。平均位置分析支持当前的范式，即佩戴接触镜期间周边角膜的水肿比中央角膜少。然而，各个位置分析揭示了一种更复杂的角膜水肿反应，与周边鼻侧和周边下方角膜水肿最少相比，佩戴接触镜2小时后，中央和颞侧中周边角膜的水肿量最大。佩戴接触镜2小时后，周边颞侧角膜和周边上方角膜的水肿与中央角膜的水肿无显著差异。佩戴接触镜2小时后，中央角膜的水肿与任何中周边位置的水肿无显著差异。本研究表明，与佩戴厚软性接触镜2小时相关的角膜水肿反应是一个复杂的动态地形学过程，不能简单地用小样本的平均数据进行建模。
