Baxendale B R, Vater M, Lavery K M
Department of Anaesthesia, Russells Hall Hospital, Dudley, West Midlands.
Anaesthesia. 1993 Nov;48(11):961-4. doi: 10.1111/j.1365-2044.1993.tb07474.x.
Extraction of multiple third molar teeth can cause significant postoperative pain, swelling and trismus, which may result in delayed hospital discharge. We have examined the effect of a single prophylactic dose of oral dexamethasone 8 mg on these complications, in a randomised double-blind study of 50 adult patients. The number of extractions performed and the operative approach were standardised. Dexamethasone resulted in a significant reduction in pain 4 h postoperatively, and eliminated the need for opioid analgesia in the postoperative period. The incidence of severe swelling was also reduced significantly, but there was no effect on trismus. Postoperative nausea and vomiting were significantly lower in the dexamethasone group. We conclude that the use of prophylactic oral dexamethasone is useful in reducing postoperative analgesia requirements in this group of patients, and may facilitate surgery performed on a day case basis.
拔除多颗第三磨牙可导致明显的术后疼痛、肿胀和牙关紧闭，这可能会导致出院延迟。在一项对50名成年患者的随机双盲研究中，我们研究了单次预防性口服8毫克地塞米松对这些并发症的影响。拔牙数量和手术方式均标准化。地塞米松使术后4小时的疼痛明显减轻，并消除了术后使用阿片类镇痛药的必要性。严重肿胀的发生率也显著降低，但对牙关紧闭没有影响。地塞米松组术后恶心和呕吐明显较少。我们得出结论，预防性口服地塞米松有助于减少该组患者的术后镇痛需求，并可能便于进行日间手术。
