Kamada K, Takihara H, Shirataki S, Ishizu K, Baba Y, Naito K
Department of Urology, Yamaguchi University School of Medicine, Kogushi, Japan.
Andrologia. 1993 Sep-Oct;25(5):239-44. doi: 10.1111/j.1439-0272.1993.tb02718.x.
It has been postulated that unilateral testicular torsion causes damage to the contralateral testis and reduces fertility. However, in animal studies such an effect has not been fully proven by histopathologic examination or other conventional assays of spermatogenesis. We investigated the effect of unilateral testicular torsion on contralateral spermatogenesis in prepubertal rats using quantitative flow cytometric DNA analysis. Male rats were divided into three groups which underwent sham-operation, simple hemiorchiectomy or unilateral testicular torsion. Five weeks after these operations, fertility and spermatogenesis by flow cytometry were evaluated. No significant differences were observed in body weight, contralateral testicular weight or serum testosterone concentration among the three experimental groups. In the torsion group, mean seminiferous tubular diameter, number of foetuses, fertility rate and percentage of haploid cells were all significantly decreased compared to the other two groups. These results suggest that unilateral testicular torsion causes damage to the contralateral testis and consequently can reduce the future fertility of prepubertal rats.
据推测，单侧睾丸扭转会对侧睾丸造成损害并降低生育能力。然而，在动物研究中，这种效应尚未通过组织病理学检查或其他常规精子发生检测得到充分证实。我们使用定量流式细胞术DNA分析，研究了单侧睾丸扭转对青春期前大鼠对侧精子发生的影响。雄性大鼠分为三组，分别接受假手术、单纯睾丸切除术或单侧睾丸扭转。这些手术后五周，通过流式细胞术评估生育能力和精子发生情况。三个实验组之间在体重、对侧睾丸重量或血清睾酮浓度方面未观察到显著差异。与其他两组相比，扭转组的平均曲细精管直径、胎儿数量、生育率和单倍体细胞百分比均显著降低。这些结果表明，单侧睾丸扭转会对侧睾丸造成损害，从而可能降低青春期前大鼠未来的生育能力。
