Salman A B, Okur D H, Tanyel F C
Department of Pediatric Surgery, Hacettepe University Medical Faculty, Ankara, Turkey.
Eur Urol. 1998 Oct;34(4):377-81. doi: 10.1159/000019744.
An experimental study was planned to evaluate if contralateral testicular deterioration following ipsilateral torsion requires the presence of a twisted ipsilateral testis and/or epididymis. Five groups, each containing 6 rats, were established. The groups underwent sham operation, epididymo-orchiectomy, testicular torsion, torsion following subepididymal orchiectomy and torsion following epididymo-orchiectomy. After 24 h, the contralateral testes were harvested and the percentage of haploid cells was determined by DNA flow cytometry. Ipsilateral torsion, in the presence and absence of testis and epididymis, significantly decreased the number of haploid cells compared to sham and epididymo-orchiectomy procedures. Torsion of only the ipsilateral spermatic cord and adjacent vasculature seemed to suffice to damage the contralateral testis. Since the presence of the ipsilateral testis and epididymis is not mandatory for this acquired damage, which occurs within 24 h, a role for a preexisting congenital defect and autoimmunity seems unlikely.
一项实验性研究旨在评估同侧睾丸扭转后对侧睾丸恶化是否需要存在扭转的同侧睾丸和/或附睾。设立了五组，每组包含6只大鼠。这些组分别接受假手术、附睾-睾丸切除术、睾丸扭转、附睾下睾丸切除术后扭转以及附睾-睾丸切除术后扭转。24小时后，采集对侧睾丸，通过DNA流式细胞术测定单倍体细胞的百分比。与假手术和附睾-睾丸切除术相比，无论同侧睾丸和附睾是否存在，同侧扭转均显著减少了单倍体细胞的数量。仅同侧精索和相邻血管的扭转似乎足以损害对侧睾丸。由于这种在24小时内发生的后天性损伤并不一定需要同侧睾丸和附睾的存在，因此先天性缺陷和自身免疫预先存在的作用似乎不太可能。
