Massey D G, Fournier-Massey G, James R H
Kuakini Medical Center, Honolulu, Hawaii.
Ann Allergy. 1993 Nov;71(5):439-44.
Dust collection and mite isolation by Furumizo's method occurred in 33 homes on days 0 and 14. The first application of Paragerm AK (23 homes) or placebo aerosol (ten homes) was done after vacuuming on day 14. The second (final) spraying occurred on day 28, immediately after vacuuming. Vacuum collections without spraying were done on days 56 and 84 in this randomized double-blind trial. With Paragerm, dust volume fell to 80.3% of initial levels by day 28, remained low at 87.9% (P < .05) on day 56, and then rose to 115.9% by day 84. In control homes, comparative dust values were 89.0%, 103.7%, and 109.9%. With Paragerm, mite concentration decreased to 70.8% by day 28 (P < .01), to 65% at day 56 (P < .025), and continued to fall to 47.7% by day 84 (P < .05). With control aerosol, mite numbers rose compared with initial values: 119.1% at day 28, 227.2% at day 56, and 125.1% at day 84. No adverse effects were observed in Paragerm homes besides odor (70% complained). The two asthmatic occupants improved symptomatically and took less medication following the Paragerm. In conclusion, Paragerm, used over 40 years in Europe, is an effective, nontoxic acaricide in Hawaii, acting promptly and for at least 2 months. It was also associated with diminished dust volume, important in nondust allergy.
采用古三法进行集尘和分离螨虫，在第0天和第14天有33户家庭参与。在第14天吸尘后，首次对23户家庭使用Paragerm AK或对10户家庭使用安慰剂气雾剂。第28天，在吸尘后立即进行第二次（也是最后一次）喷洒。在这项随机双盲试验中，第56天和第84天进行了不喷洒的吸尘收集。使用Paragerm后，到第28天灰尘量降至初始水平的80.3%，第56天仍保持在较低水平，为87.9%（P < 0.05），到第84天升至115.9%。在对照家庭中，相应的灰尘值分别为89.0%、103.7%和109.9%。使用Paragerm后，螨虫浓度到第28天降至70.8%（P < 0.01），第56天降至65%（P < 0.025），到第84天继续降至47.7%（P < 0.05）。使用对照气雾剂后，螨虫数量与初始值相比有所增加：第28天为119.1%，第56天为227.2%，第84天为125.1%。在使用Paragerm的家庭中，除了有气味（70%的人抱怨）外，未观察到其他不良反应。两名哮喘患者在使用Paragerm后症状有改善，用药量减少。总之，在欧洲已使用40多年的Paragerm在夏威夷是一种有效的无毒杀螨剂，起效迅速且作用至少持续2个月。它还能减少灰尘量，这对非灰尘过敏很重要。
