Dohlmann G F
Arch Otorhinolaryngol. 1976 Sep 16;212(4):301-7. doi: 10.1007/BF00453678.
Three theories are discussed dealing with the origin of the Menière attack: 1) The hypothesis of pressure induced changes is disproved. 2. The stimulation of the crista epithelium by a mechanical cupula deviation has been investigated. The results showed that the changes in action potential frequency of the ampullary nerve induced by maintained bending of the cupula, always declined and returned to resting potential frequency within a very short period of time usually within 1 min. Preventing the "elastic return" of the cupula did not change the time constant of this response decline. This proves that a Menière nystagmus lasting for hours, can not be elicited by a mechanical deformation of the cupula. 3) The paralyzing influence on vestibular nerve fibres by K+ ions in endolymph, leaking into perilymph spaces has earlier been demonstrated by the author. When the distended membranous labyrinth ruptures at predestined weak spots, leaking endolymph may reach and paralyze different nerve branches. This can explain all the main symptoms of a Menière attack.
1）压力诱导变化的假说已被推翻。2）对机械性椭圆囊斑偏移刺激嵴上皮进行了研究。结果表明，由椭圆囊斑持续弯曲引起的壶腹神经动作电位频率变化，总是在很短时间内（通常在1分钟内）下降并恢复到静息电位频率。阻止椭圆囊斑的“弹性恢复”并没有改变这种反应下降的时间常数。这证明椭圆囊斑的机械变形无法引发持续数小时的梅尼埃眼震。3）作者之前已经证明，内淋巴中的钾离子泄漏到外淋巴间隙会对前庭神经纤维产生麻痹作用。当扩张的膜迷路在预定的薄弱部位破裂时，泄漏的内淋巴可能会到达并麻痹不同的神经分支。这可以解释梅尼埃病发作的所有主要症状。
