Sabater R, Saez J A, Ferrer J M
Department of Physiology, School of Medicine, University of Granada, Spain.
Eur J Pharmacol. 1993 Sep 28;242(2):205-8. doi: 10.1016/0014-2999(93)90082-s.
We studied the effects of peripheral and central administration of SCH 23390, a selective antagonist of dopamine D1 receptors, on intracranial self-stimulation of the medial prefrontal cortex of the rat. Intraperitoneal injections of SCH 23390 produced a dose-related decrease in self-stimulation. Unilateral microinjections of SCH 23390 into the medial prefrontal cortex also produced a dose-related decrease in self-stimulation in the ipsilateral medial prefrontal cortex. However, self-stimulation of the contralateral, noninjected prefrontal cortex, used as control, was not affected. Together with previous data, the present results suggest that the dopamine neurotransmission involved in self-stimulation of the prefrontal cortex of the rat is mediated by dopamine D1 receptors.
我们研究了多巴胺D1受体选择性拮抗剂SCH 23390外周和中枢给药对大鼠内侧前额叶皮质颅内自我刺激的影响。腹腔注射SCH 23390可使自我刺激产生剂量相关的减少。将SCH 23390单侧微量注射到内侧前额叶皮质也可使同侧内侧前额叶皮质的自我刺激产生剂量相关的减少。然而，作为对照的对侧未注射前额叶皮质的自我刺激不受影响。结合先前的数据，目前的结果表明，大鼠前额叶皮质自我刺激中涉及的多巴胺神经传递是由多巴胺D1受体介导的。
