Thornton J A, Malkova L, Murray E A
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892-4415, USA.
Behav Neurosci. 1998 Aug;112(4):1020-5. doi: 10.1037//0735-7044.112.4.1020.
Studies have shown that excitotoxic lesions of the amygdala attenuate reinforcer devaluation effects in monkeys and rats. Because the rhinal (i.e., entorhinal and perirhinal) cortex has prominent reciprocal connections with the amygdala and has been suggested to store knowledge about objects, it is possible that it too composes part of the critical circuitry subserving learning about objects and their associated reinforcement value. To test this possibility, rhesus monkeys with rhinal cortex removals as well as unoperated controls were tested using a reinforcer devaluation procedure. Monkeys with rhinal cortex removals and controls, unlike those with amygdala lesions, tended to avoid displacing objects overlying a devalued food. These results indicate that the rhinal cortex is not a critical part of the neural circuitry mediating the effects of reinforcer devaluation.
研究表明，杏仁核的兴奋性毒性损伤会减弱猴子和大鼠的强化物贬值效应。由于嗅周皮质（即内嗅皮质和嗅旁皮质）与杏仁核有显著的相互连接，并且有人提出它负责存储关于物体的知识，所以它也有可能构成了服务于物体及其相关强化价值学习的关键神经回路的一部分。为了验证这种可能性，我们使用强化物贬值程序对切除嗅周皮质的恒河猴以及未手术的对照组进行了测试。与杏仁核损伤的猴子不同，切除嗅周皮质的猴子和对照组倾向于避免移开覆盖在贬值食物上的物体。这些结果表明，嗅周皮质不是介导强化物贬值效应的神经回路的关键部分。
