Lifshits M, Yagupsky P, Sofer S
Division of Pediatrics, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Toxicol Clin Toxicol. 1993;31(4):653-6. doi: 10.3109/15563659309025769.
A 6 year-old child with paraphenylenediamine intoxication is presented. The patient suffered from sore throat, cough, and anorexia, followed by severe dyspnea caused by edema of the tongue, pharynx, and neck, renal failure, and metabolic acidosis. A presumptive diagnosis of Ludwig's angina, a severe anaerobic infection of the sublingual neck space, was entertained. Despite institution of vigorous supportive therapy and administration of antibiotics, the child developed irreversible ventricular fibrillation and died eight hours after admission. Two days after the patient's death, his father recalled that the child and his dog ingested an unidentified substance shortly before the onset of the child's symptoms. The dog died within a few hours. The substance was identified as the hair dye, paraphenylenediamine.
本文报告了一名6岁的对苯二胺中毒儿童。该患者出现咽痛、咳嗽和厌食，随后因舌、咽和颈部水肿、肾衰竭和代谢性酸中毒导致严重呼吸困难。初步诊断为路德维希咽峡炎，这是一种舌下颈部间隙的严重厌氧菌感染。尽管采取了积极的支持治疗并使用了抗生素，但该儿童仍发生了不可逆的心室颤动，并在入院8小时后死亡。患者死亡两天后，他的父亲回忆说，孩子和他的狗在孩子症状出现前不久摄入了一种不明物质。狗在几小时内死亡。该物质被确认为染发剂对苯二胺。
