Yagi H, el Hind A M, Khalil S I
Faculty of Medicine, University of Khartoum, Sudan.
East Afr Med J. 1991 Jun;68(6):404-11.
A series of 18 cases of acute hair dye (paraphenylenediamine) poisoning were reported. The characteristic features of swollen face and the chocolate brown colour of the urine were diagnostic. Asphyxia was found to be the major early challenge of life. Tracheostomy and intensive medical treatment with hydrocortisone and chlorpheniramine maleate (antihistaminic drug) and penicillin cover were life saving in all serious cases. The mild cases were successfully treated with hydrocortisone and chlorpheniramine maleate and penicillin without tracheostomy. The dye was detected in the urine by thin layer chromatography on silica gel and proved to be paraphenylenediamine. Early prompt diagnosis and clinical management proved to be life saving in both serious or mild hair dye poisoning.
报告了18例急性染发剂（对苯二胺）中毒病例。面部肿胀和尿液呈巧克力棕色是其特征性表现，具有诊断价值。发现窒息是早期主要的生命威胁。在所有严重病例中，气管切开术以及使用氢化可的松、马来酸氯苯那敏（抗组胺药）进行强化治疗并给予青霉素覆盖可挽救生命。轻症病例使用氢化可的松、马来酸氯苯那敏和青霉素治疗成功，无需气管切开术。通过硅胶薄层色谱法在尿液中检测到该染料，证实为对苯二胺。早期及时诊断和临床处理在严重或轻度染发剂中毒病例中均被证明可挽救生命。
