Chaudhary S C, Sawlani K K, Singh K
Department of Medicine, C. S. M. Medical University, Lucknow, India.
Niger J Clin Pract. 2013 Apr-Jun;16(2):258-9. doi: 10.4103/1119-3077.110138.
Hair dye containing paraphenylenediamine (PPD) is widely used in India because of its free availability and low cost. PPD produces local as well as systemic toxic effects when applied topically and/or ingested. It is highly toxic when taken by mouth and the outcome depends mainly on the dose taken. Important clinical manifestations are angioedema leading to dysphasia and respiratory distress, rhabdomyolysis, intravascular hemolysis, acute renal failure and hepatic necrosis. Myocarditis or fatal arrhythmia may also occur in PPD poisoning. Mainstay of management is early recognition and supportive measures as there is no specific antidote. We hereby report a young female who presented to us with features of angioedema, cardiac manifestation and hepatic dysfunction after ingesting PPD, which was treated successfully. In the absence of laboratory facilities, clinical features like angioedema and chocolate brown-colored urine could be suggestive of PPD poisoning.
由于对苯二胺（PPD）染发剂在印度容易获取且成本低廉，因此被广泛使用。局部应用和/或摄入PPD时会产生局部和全身毒性作用。口服时毒性很高，其后果主要取决于服用剂量。重要的临床表现为血管性水肿导致吞咽困难和呼吸窘迫、横纹肌溶解、血管内溶血、急性肾衰竭和肝坏死。PPD中毒时也可能发生心肌炎或致命性心律失常。由于没有特效解毒剂，治疗的关键是早期识别和采取支持措施。我们在此报告一名年轻女性，她在摄入PPD后出现血管性水肿、心脏表现和肝功能障碍等症状，并得到了成功治疗。在缺乏实验室检查设施的情况下，血管性水肿和巧克力棕色尿液等临床特征可能提示PPD中毒。
