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1
Rubella hemagglutination-inhibition test: false-positive reactions in sera contaminated with bacteria.风疹血凝抑制试验：被细菌污染的血清中的假阳性反应。
J Clin Microbiol. 1976 Nov;4(5):389-93. doi: 10.1128/jcm.4.5.389-393.1976.
2
Nonspecific reactions in the hemagglutination inhibition test for detection of rubella antibodies.用于检测风疹抗体的血凝抑制试验中的非特异性反应。
J Clin Microbiol. 1981 May;13(5):818-23. doi: 10.1128/jcm.13.5.818-823.1981.
3
Use of sodium polyanetholesulfonate-CaCl2 for removal of serum nonspecific inhibitors of rubella hemagglutination: comparison with other polyanion-divalent cation combinations.使用聚茴香脑磺酸钠-氯化钙去除风疹血凝反应的血清非特异性抑制剂：与其他聚阴离子-二价阳离子组合的比较。
J Clin Microbiol. 1977 Oct;6(4):348-58. doi: 10.1128/jcm.6.4.348-358.1977.
4
False positive rubella virus haemagglutination inhibition reactions: occurrence and disclosure.风疹病毒血凝抑制反应假阳性：发生率与披露情况
Med Microbiol Immunol. 1975;161(2):99-106. doi: 10.1007/BF02121750.
5
Variables of the rubella hemagglutination-inhibition test system and their effect on antigen and antibody titers.风疹血凝抑制试验系统的变量及其对抗原和抗体滴度的影响。
Appl Microbiol. 1970 Mar;19(3):491-504. doi: 10.1128/am.19.3.491-504.1970.
6
[Removal of nonspecific inhibitors in the Rubella virus hemagglutination inhibition test employing acetone as compared to kaolin and heparin-MnCl2 pretreatment (author's transl)].风疹病毒血凝抑制试验中采用丙酮与高岭土及肝素 - 氯化锰预处理相比去除非特异性抑制剂（作者译）
Zentralbl Bakteriol Orig A. 1974;229(3):290-8.
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Experience with a modified rubella hemagglutination inhibition antibody test.改良风疹血凝抑制抗体试验的经验
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8
Evaluation of commercially available diagnostic test kits for rubella.风疹商用诊断检测试剂盒的评估
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9
Modified hemagglutination-inhibition test for rubella employing human group O erythrocytes.采用人O型红细胞的风疹改良血凝抑制试验。
Appl Microbiol. 1972 Mar;23(3):471-5. doi: 10.1128/am.23.3.471-475.1972.
10
Improved rubella hemagglutination inhibtion test: inactivation of non-immunoglobulin hemagglutination inhibitors by phospholipase C.改良风疹血凝抑制试验：用磷脂酶C使非免疫球蛋白血凝抑制剂失活
J Clin Microbiol. 1976 Dec;4(6):461-6. doi: 10.1128/jcm.4.6.461-466.1976.

引用本文的文献

1
Nonspecific reactions in the hemagglutination inhibition test for detection of rubella antibodies.用于检测风疹抗体的血凝抑制试验中的非特异性反应。
J Clin Microbiol. 1981 May;13(5):818-23. doi: 10.1128/jcm.13.5.818-823.1981.
2
An inhibitor to rubella hemagglutination present in bovine albumin preparations: its removal by treatment with kaolin.牛白蛋白制剂中存在的风疹血凝抑制物：用高岭土处理将其去除。
Med Microbiol Immunol. 1977 Jul 18;163(2):83-92. doi: 10.1007/BF02121823.
3
Use of sodium polyanetholesulfonate-CaCl2 for removal of serum nonspecific inhibitors of rubella hemagglutination: comparison with other polyanion-divalent cation combinations.使用聚茴香脑磺酸钠-氯化钙去除风疹血凝反应的血清非特异性抑制剂：与其他聚阴离子-二价阳离子组合的比较。
J Clin Microbiol. 1977 Oct;6(4):348-58. doi: 10.1128/jcm.6.4.348-358.1977.

本文引用的文献

1
Modified hemagglutination-inhibition test for rubella employing human group O erythrocytes.采用人O型红细胞的风疹改良血凝抑制试验。
Appl Microbiol. 1972 Mar;23(3):471-5. doi: 10.1128/am.23.3.471-475.1972.
2
Identification of non-specific serum inhibitors of rubella virus haemagglutination.风疹病毒血凝反应非特异性血清抑制剂的鉴定
Med Microbiol Immunol. 1974 Jun 19;159(4):271-7. doi: 10.1007/BF02123736.
3
Use of trypsin-modified human erythrocytes in rubella hemagglutination-inhibition testing.胰蛋白酶修饰的人红细胞在风疹血凝抑制试验中的应用。
Appl Microbiol. 1972 Sep;24(3):353-7. doi: 10.1128/am.24.3.353-357.1972.
4
A rubella haemagglutination inhibitor simulating antibody.一种模拟抗体的风疹血凝抑制物。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Dec;81(6):719-23. doi: 10.1111/j.1699-0463.1973.tb02266.x.
5
Rubella hemagglutination inhibition: removal of nonspecific agglutination due to manganous chloride.风疹血凝抑制：去除因氯化锰导致的非特异性凝集。
Appl Microbiol. 1974 Dec;28(6):992-4. doi: 10.1128/am.28.6.992-994.1974.
6
A rountine diagnostic test for IgA and IgM antibodies to rubella virus: absorption of IgG with Staphylococcus aureus.风疹病毒IgA和IgM抗体的常规诊断试验：用金黄色葡萄球菌吸收IgG
J Infect Dis. 1974 Sep;130(3):268-73. doi: 10.1093/infdis/130.3.268.
7
Changes in lipid values and lipoprotein patterns of serum samples contaminated with bacteria.被细菌污染的血清样本的脂质值和脂蛋白模式的变化。
Am J Clin Pathol. 1973 Jun;59(6):829-35. doi: 10.1093/ajcp/59.6.829.
8
Cell agglutinating activities of some enteric bacteria and effects of various factors on bacteria-tumor cell agglutination.某些肠道细菌的细胞凝集活性及各种因素对细菌-肿瘤细胞凝集的影响。
Sci Rep Res Inst Tohoku Univ Med. 1974 Jul;21(1-2):10-6.
9
Letter: Rubella-specific IgM and a new inhibitor.信件：风疹特异性IgM与一种新型抑制剂。
Br Med J. 1974 Aug 31;3(5930):579. doi: 10.1136/bmj.3.5930.579-c.
10
Rubella reinfection during pregnancy. A case of mistaken diagnosis of congenital rubella.孕期风疹再感染。一例先天性风疹误诊病例。
Am J Dis Child. 1975 Nov;129(11):1353-6. doi: 10.1001/archpedi.1975.02120480065017.

风疹血凝抑制试验：被细菌污染的血清中的假阳性反应。

Rubella hemagglutination-inhibition test: false-positive reactions in sera contaminated with bacteria.

作者信息

Campbell J B, Romach M, Ellins M L

出版信息

J Clin Microbiol. 1976 Nov;4(5):389-93. doi: 10.1128/jcm.4.5.389-393.1976.

DOI:10.1128/jcm.4.5.389-393.1976
PMID:825529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC274485/
Abstract

We have shown that bacterial contamination of sera can have a marked influence on the results of the rubella hemagglutination-inhibition (HI) test. In addition to increasing the levels of nonspecific agglutinins, a number of common bacterial species tested had a significant effect on the HI titers. When sera free from rubella-specific antibodies were contaminated with Bacillus subtilis or Pseudomonas fluorescens, HI titers ranged from 16 to 128 (expressed as the reciprocal of the highest serum dilution completely inhibiting hemagglutination) after treatment with heparin/MnCl2. Our observations demonstrate, therefore, that bacterial contamination can be one of the causes of false-positive reactions in this test.

摘要

我们已经表明，血清的细菌污染会对风疹血凝抑制（HI）试验的结果产生显著影响。除了增加非特异性凝集素水平外，所检测的一些常见细菌种类对HI滴度有显著影响。当不含风疹特异性抗体的血清被枯草芽孢杆菌或荧光假单胞菌污染时，用肝素/氯化锰处理后，HI滴度范围为16至128（表示为完全抑制血凝的最高血清稀释倍数的倒数）。因此，我们的观察结果表明，细菌污染可能是该试验假阳性反应的原因之一。