• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种用于哺乳动物细胞的形态生物传感器。

A morphological biosensor for mammalian cells.

作者信息

Giaever I, Keese C R

机构信息

School of Science, Rensselaer Polytechnic Institute, Troy, New York 12180-3590.

出版信息

Nature. 1993 Dec 9;366(6455):591-2. doi: 10.1038/366591a0.

DOI:10.1038/366591a0
PMID:8255299
Abstract

An electrical biosensor is described that can continuously track morphological changes of adherent cells providing quantitative data from both sparse and confluent cultures. The method is capable of detecting vertical motion of cells of the order of 1 nm, much below the resolution of an optical microscope.

摘要

本文描述了一种电化学生物传感器，它能够连续跟踪贴壁细胞的形态变化，为稀疏培养和汇合培养提供定量数据。该方法能够检测到约1纳米量级的细胞垂直运动，远低于光学显微镜的分辨率。

相似文献

1
A morphological biosensor for mammalian cells.一种用于哺乳动物细胞的形态生物传感器。
Nature. 1993 Dec 9;366(6455):591-2. doi: 10.1038/366591a0.
2
Quartz crystal microbalance study of endothelial cell number dependent differences in initial adhesion and steady-state behavior: evidence for cell-cell cooperativity in initial adhesion and spreading.基于石英晶体微天平研究内皮细胞数量对初始黏附及稳态行为的依赖性差异：初始黏附与铺展过程中细胞间协同作用的证据
Biotechnol Prog. 2003 May-Jun;19(3):987-99. doi: 10.1021/bp0201096.
3
Techniques for studying the electrophysiology of neurons derived from neural stem/progenitor cells.研究源自神经干细胞/祖细胞的神经元电生理学的技术。
Methods Mol Biol. 2002;198:179-86. doi: 10.1385/1-59259-186-8:179.
4
Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells.人血源性巨噬细胞增强原代培养的牛和人脑微血管内皮细胞的屏障功能。
J Physiol. 2003 Sep 15;551(Pt 3):1023-32. doi: 10.1113/jphysiol.2003.045880. Epub 2003 Jun 26.
5
A comparative study of the cytoskeleton binding drugs nocodazole and taxol with a mammalian cell quartz crystal microbalance biosensor: different dynamic responses and energy dissipation effects.用哺乳动物细胞石英晶体微天平生物传感器对细胞骨架结合药物诺考达唑和紫杉醇进行的比较研究：不同的动态响应和能量耗散效应。
Anal Biochem. 2007 Feb 1;361(1):77-92. doi: 10.1016/j.ab.2006.09.023. Epub 2006 Oct 19.
6
Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats.细胞黏附分子在癌与内皮细胞共移植诱导裸鼠肿瘤血管生成中的作用
Cancer Res. 2002 Nov 1;62(21):6289-96.
7
NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity.NM-3，一种异香豆素，可增强放射疗法的抗肿瘤效果且无毒性。
Cancer Res. 2000 Dec 15;60(24):6958-63.
8
Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of beta1-integrin and phosphatidylinositol 3-kinase/Akt.与内皮细胞共培养通过激活β1整合素和磷脂酰肌醇3激酶/蛋白激酶B增强血管平滑肌细胞的黏附与铺展。
Eur J Cell Biol. 2007 Jan;86(1):51-62. doi: 10.1016/j.ejcb.2006.09.001. Epub 2006 Dec 4.
9
Involvement of H type 1 carbohydrate antigen in cell adhesion to vascular endothelial cells of human endometrial cancer.1型H抗原在人子宫内膜癌细胞与血管内皮细胞黏附中的作用
Anticancer Res. 2003 Mar-Apr;23(2B):1277-82.
10
Recruitment of Chlamydia pneumoniae-infected macrophages to the carotid artery wall in noninfected, nonatherosclerotic mice.在未感染、无动脉粥样硬化的小鼠中，肺炎衣原体感染的巨噬细胞向颈动脉壁的募集。
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):789-94. doi: 10.1161/01.ATV.0000068645.60805.7C. Epub 2003 Mar 27.

引用本文的文献

1
Label-free live cell recognition and tracking for biological discoveries and translational applications.用于生物学发现和转化应用的无标记活细胞识别与追踪
Npj Imaging. 2024 Oct 7;2(1):41. doi: 10.1038/s44303-024-00046-y.
2
The Potential Role of SP-G and PLUNC in Tumor Pathogenesis and Wound Healing in the Human Larynx.表面活性蛋白G和腭肺鼻上皮癌相关蛋白在人喉肿瘤发病机制及伤口愈合中的潜在作用
Biomedicines. 2025 May 20;13(5):1240. doi: 10.3390/biomedicines13051240.
3
Is laccase from medicinal mushroom Cerrena unicolor cytotoxic to colon cancer cell line CT-26?
来自药用真菌单色蜡蘑的漆酶对结肠癌细胞系CT-26具有细胞毒性吗？
PLoS One. 2025 May 8;20(5):e0322211. doi: 10.1371/journal.pone.0322211. eCollection 2025.
4
Accelerating the Understanding of Biosensors Through the Lens of Cells: State of the Field, Emerging Directions, Advances, and Challenges.从细胞视角加速对生物传感器的理解：该领域现状、新兴方向、进展与挑战
Appl Biochem Biotechnol. 2025 Apr 5. doi: 10.1007/s12010-025-05209-0.
5
Glyceraldehyde-3-phosphate dehydrogenase/1,3-bisphosphoglycerate-NADH as key determinants in controlling human retinal endothelial cellular functions: Insights from glycolytic screening.3-磷酸甘油醛脱氢酶/1,3-二磷酸甘油酸-NADH作为控制人视网膜内皮细胞功能的关键决定因素：来自糖酵解筛选的见解
J Biol Chem. 2025 May;301(5):108472. doi: 10.1016/j.jbc.2025.108472. Epub 2025 Mar 28.
6
Implantable Biosensors for Vascular Diseases: Directions for the Next Generation of Active Diagnostic and Therapeutic Medical Device Technologies.用于血管疾病的可植入生物传感器：下一代主动诊断和治疗医疗设备技术的发展方向。
Biosensors (Basel). 2025 Feb 25;15(3):147. doi: 10.3390/bios15030147.
7
Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology.颠覆药物发现：基于微流控的器官芯片技术中独特设计和生物传感器集成的影响。
Biosensors (Basel). 2024 Sep 3;14(9):425. doi: 10.3390/bios14090425.
8
Optimizing Ex Vivo CAR-T Cell-Mediated Cytotoxicity Assay through Multimodality Imaging.通过多模态成像优化离体CAR-T细胞介导的细胞毒性测定
Cancers (Basel). 2024 Jul 9;16(14):2497. doi: 10.3390/cancers16142497.
9
Cell-Electrode Models for Impedance Analysis of Epithelial and Endothelial Monolayers Cultured on Microelectrodes.基于微电极上培养的上皮和内皮单层细胞的阻抗分析的细胞-电极模型。
Sensors (Basel). 2024 Jun 28;24(13):4214. doi: 10.3390/s24134214.
10
Bioimpedance analysis for identifying new indicators of exercise-induced muscle damage.生物阻抗分析在识别运动诱导肌肉损伤新指标中的应用。
Sci Rep. 2024 Jul 3;14(1):15299. doi: 10.1038/s41598-024-66089-8.