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Is morphine dependence mediated exclusively by the Mu receptor?

作者信息

Adams R E, Wooten G F

机构信息

Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908.

出版信息

Neurochem Res. 1993 Oct;18(10):1041-5. doi: 10.1007/BF00966681.

DOI:10.1007/BF00966681
PMID:8255352
Abstract

Regional cerebral glucose utilization (RCGU) and behavior during naloxone precipitated withdrawal were studied in rats made dependent on either sufentanil, a highly selective mu opiate agonist, or morphine. Changes in RCGU during withdrawal in 23 of 24 anatomically related limbic and brainstem structures were indistinguishable between rats dependent on morphine or sufentanil. Linear regression analysis indicated that RCGU changes during withdrawal in these two groups were highly correlated (r = 0.95). Withdrawal behaviors (autonomic signs of withdrawal, jumps, weight loss, and incidence of diarrhea) were likewise indistinguishable between the two groups. The correlations of both these measurements of dependence suggest that chronic occupation of mu opiate receptors alone is sufficient to produce dependence that is indistinguishable from morphine dependence.

摘要

相似文献

1
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引用本文的文献

1
Regional cerebral glucose utilization in withdrawal following systemic and intracerebroventricular sufentanil administration.
Neurochem Res. 1994 Oct;19(10):1243-8. doi: 10.1007/BF01006813.

本文引用的文献

1
Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity.大鼠垂体后叶中依赖活动的能量代谢主要反映钠泵活性。
J Neurochem. 1980 Jan;34(1):213-5. doi: 10.1111/j.1471-4159.1980.tb04643.x.
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Regional cerebral glucose utilization during morphine withdrawal in the rat.大鼠吗啡戒断期间的局部脑葡萄糖利用情况
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A behavioral and 2-deoxyglucose autoradiographic study of the effects of cumulative morphine dose on naloxone precipitated withdrawal in the rat.
一项关于累积吗啡剂量对大鼠纳洛酮诱发戒断反应影响的行为学和2-脱氧葡萄糖放射自显影研究。
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Are there subtypes (isoreceptors) of multiple opiate receptors in the mouse vas deferens?小鼠输精管中是否存在多种阿片受体的亚型（同种受体）？
Eur J Pharmacol. 1981 Nov 19;76(1):61-6. doi: 10.1016/0014-2999(81)90009-1.
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The direction of opiodid agonists towards mu-, delta- and epsilon-receptors in the vas deferens of the mouse and the rat.
Life Sci. 1980 Jul 14;27(2):163-70. doi: 10.1016/0024-3205(80)90459-2.
6
[3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord.[3H]舒芬太尼，一种μ-阿片受体的优质配体：在大鼠脑和脊髓中的结合特性及区域分布
Eur J Pharmacol. 1983 Feb 18;87(2-3):209-25. doi: 10.1016/0014-2999(83)90331-x.
7
Similar functional anatomy of spontaneous and precipitated morphine withdrawal.自发和诱发的吗啡戒断的相似功能解剖学。
Brain Res. 1985 May 13;334(1):183-6. doi: 10.1016/0006-8993(85)90585-2.
8
Dose effects of naloxone on fixed morphine dependence: simultaneous behavioral and 2-deoxyglucose study in the rat.纳洛酮对固定吗啡依赖的剂量效应：大鼠行为与2-脱氧葡萄糖同步研究
Brain Res. 1985 Apr 15;332(1):69-78. doi: 10.1016/0006-8993(85)90390-7.
9
Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat.电刺激大鼠坐骨神经对脊髓和背根神经节代谢活性的不同影响。
Proc Natl Acad Sci U S A. 1985 Sep;82(17):6010-3. doi: 10.1073/pnas.82.17.6010.
10
Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain.大鼠前脑和中脑μ、δ和κ阿片受体的放射自显影鉴别
J Neurosci. 1987 Aug;7(8):2445-64.