人成纤维细胞对淋巴细胞衍生因子的趋化吸引作用。
The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor.
作者信息
Postlethwaite A E, Snyderman R, Kang A H
出版信息
J Exp Med. 1976 Nov 2;144(5):1188-203. doi: 10.1084/jem.144.5.1188.
Abstract
A quantitative assay that measures fibroblast chemotaxis in vitro is described. Application of this technique has revealed that peripheral blood lymphocytes stimulated by antigen or mitogen in vitro produce a factor that is chemotactic for human dermal fibroblasts. This lymphocyte-derived chemotactic factor for fibroblasts (LDCF-F) is different from the lymphokine that is chemotactic for monocytes or macrophages. Macrophages are required for the generation of LDCF-F by T lymphocytes stimulated by phytohemagglutinin. The fibroblast chemotactic factor is heat stable (56 degrees C for 30 min), trypsin sensitive, and neuraminidase resistant. LDCF-F could function to attact connective tissue fibroblasts to sites at which cell-mediated immune reactions are occurring in vivo.
摘要
本文描述了一种用于体外测量成纤维细胞趋化性的定量检测方法。应用该技术已发现，体外受抗原或丝裂原刺激的外周血淋巴细胞可产生一种对人真皮成纤维细胞具有趋化作用的因子。这种由淋巴细胞产生的对成纤维细胞的趋化因子（LDCF-F）不同于对单核细胞或巨噬细胞具有趋化作用的淋巴因子。巨噬细胞是由植物血凝素刺激的T淋巴细胞产生LDCF-F所必需的。成纤维细胞趋化因子热稳定（56℃，30分钟），对胰蛋白酶敏感，对神经氨酸酶有抗性。LDCF-F可能起到将结缔组织成纤维细胞吸引到体内发生细胞介导免疫反应的部位的作用。
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