Pulito A R, Santulli T V, Wigger H J, Bieber M A, Heird W C
J Pediatr Surg. 1976 Oct;11(5):655-63. doi: 10.1016/0022-3468(76)90087-7.
The effects on hepatic growth of fat-free TPN and semistarvation have been studied in newborn beagle puppies. Our data indicate that liver growth during TPN is characterized by normal deposition of protein and minerals, with increased glycogen and decreased lipid content. While the lipid pattern of TPN livers is normal, the phospholipid fraction contains an abnormal fatty acid pattern, consistent with the development of essential fatty acid deficiency. The exact physiologic significance of this is unknown, but it is tempting to speculate that changes in integrity of the hepatic cell membrane as a result of this abnormal fatty acid pattern might account for some of the clinical abnormalities of hepatic function during TPN.
已在新生比格幼犬中研究了无脂全胃肠外营养（TPN）和半饥饿对肝脏生长的影响。我们的数据表明，TPN期间肝脏生长的特征是蛋白质和矿物质正常沉积，糖原增加，脂质含量降低。虽然TPN肝脏的脂质模式正常，但磷脂部分含有异常的脂肪酸模式，这与必需脂肪酸缺乏的发展一致。其确切的生理意义尚不清楚，但很诱人地推测，这种异常脂肪酸模式导致的肝细胞膜完整性变化可能是TPN期间肝功能某些临床异常的原因。
