Malloy M H, Rassin D K, Gaull G E, Heird W C
Biol Neonate. 1981;40(1-2):1-8. doi: 10.1159/000241466.
In beagle pups (from 5 to 84 days of age), plasma taurine concentration decreased between 5 and 21 days of age with no change thereafer; cerebral taurine concentration decreased throughout the period of study but cerebral taurine content increased between 5 and 21 days of age; hepatic taurine content (but not concentration) increased throughout. Both hepatic cysteinesulfinic acid decarboxylase (CSAD) activity and the concentration of taurine-conjugated bile acid of gallbladder bile increased during the period of study. Plasma and cerebral taurine pools were not affected by taurine-free total parenteral nutrition (TPN). Hepatic taurine content was also not affected, but taurine concentration decreased; however, this change resulted from an increase in hepatic size. Hepatic CSAD activity of animals that received TPN was greater than that of 35-day control animals while the concentration of taurine-conjugated bile acids in the gallbladder bile was less. Although plasma taurine concentration was not affected by intravenous glucose therapy, both the hepatic taurine concentration and content of these animals were less than those of 35-day control animals. Cerebral taurine concentration of these animals, on the other hand, were greater. Hepatic CSAD activity of the animals that received only intravenous glucose was similar to that of controls, but the taurine-conjugated bile acid concentration in the gallbladder bile, like that of animals that received TPN, was less than that observed in 35-day control animals.
在比格幼犬（5至84日龄）中，血浆牛磺酸浓度在5至21日龄之间下降，此后无变化；脑牛磺酸浓度在整个研究期间下降，但脑牛磺酸含量在5至21日龄之间增加；肝脏牛磺酸含量（而非浓度）在整个期间增加。在研究期间，肝脏半胱氨酸亚磺酸脱羧酶（CSAD）活性和胆囊胆汁中牛磺酸结合型胆汁酸的浓度均增加。无牛磺酸的全胃肠外营养（TPN）对血浆和脑牛磺酸池无影响。肝脏牛磺酸含量也未受影响，但牛磺酸浓度下降；然而，这种变化是由于肝脏体积增大所致。接受TPN的动物的肝脏CSAD活性高于35日龄对照动物，而胆囊胆汁中牛磺酸结合型胆汁酸的浓度较低。尽管静脉注射葡萄糖治疗未影响血浆牛磺酸浓度，但这些动物的肝脏牛磺酸浓度和含量均低于35日龄对照动物。另一方面，这些动物的脑牛磺酸浓度较高。仅接受静脉注射葡萄糖的动物的肝脏CSAD活性与对照动物相似，但胆囊胆汁中牛磺酸结合型胆汁酸的浓度与接受TPN的动物一样，低于35日龄对照动物。
