Paulus W, Jellinger K
Institute of Pathology, University of Würzburg, School of Medicine, Germany.
Acta Neuropathol. 1993;86(4):360-4. doi: 10.1007/BF00369448.
The expression of 17 adhesion molecules was immunohistochemically examined in 5 primary cerebral lymphomas (PCL) and in 5 histologically similar nodal lymphomas (NL) to evaluate their possible involvement in selective targeting of lymphoma cells to the brain. PCL and NL tumor cells showed very similar expression patterns: they were consistently positive for alpha 3, alpha 4 and beta 1 integrin chains; negative for alpha 1, alpha 2, alpha 6, beta 3 and beta 4 integrin chains; and heterogeneous for alpha 5, alpha L, alpha M, alpha X, beta 2 and beta 7 integrin chains, as well as for intercellular adhesion molecule-1 (ICAM-1) and the selectin LECAM-1. Loosely infiltrating PCL showed lower levels of the alpha L beta 2 integrin than compact cell clusters. Vessels stained for ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1). We conclude that the adhesion molecules implicated in the extravasation of non-neoplastic leukocytes (alpha 4 beta 1/VCAM-1 and alpha L beta 2/ICAM-1) are also expressed by both PCL and NL. The adhesion molecules examined are apparently not selective mediators of lymphoma cell homing to the brain, but at least alpha L beta 2 integrin might be related to the infiltration pattern of PCL within the brain parenchyma.
采用免疫组织化学方法检测了5例原发性脑淋巴瘤（PCL）和5例组织学上相似的淋巴结淋巴瘤（NL）中17种黏附分子的表达，以评估它们在淋巴瘤细胞选择性靶向脑转移过程中可能发挥的作用。PCL和NL肿瘤细胞表现出非常相似的表达模式：它们始终对α3、α4和β1整合素链呈阳性；对α1、α2、α6、β3和β4整合素链呈阴性；对α5、αL、αM、αX、β2和β7整合素链以及细胞间黏附分子-1（ICAM-1）和选择素LECAM-1呈异质性表达。松散浸润的PCL中αLβ2整合素水平低于紧密细胞簇。血管内皮细胞ICAM-1和血管细胞黏附分子-1（VCAM-1）染色阳性。我们得出结论，参与非肿瘤性白细胞外渗的黏附分子（α4β1/VCAM-1和αLβ2/ICAM-1）在PCL和NL中均有表达。所检测的黏附分子显然不是淋巴瘤细胞归巢至脑的选择性介质，但至少αLβ2整合素可能与PCL在脑实质内的浸润模式有关。
