Valette M, Allard J P, Aymard M, Millet V
Laboratoire de Virologie, Universite Claude Bernard-Lyon 1, France.
Antimicrob Agents Chemother. 1993 Oct;37(10):2239-40. doi: 10.1128/AAC.37.10.2239.
Clinical isolates of influenza A viruses identified during outbreaks in two winters were tested for their rimantadine susceptibilities by an enzyme-linked immunosorbent assay modified from that described previously by Belshe et al. (R. B. Belshe, B. Burk, F. Newman, R. L. Cerruti, and I. S. Sim, J. Virol. 62:1508-1512, 1988). The infectivity titer and the 50% inhibitory concentration of rimantadine were calculated for each virus. Of 105 influenza virus A isolates tested, 28 influenza A/H1N1 isolates from the 1988 and 1989 outbreak and 77 influenza A/H3N2 isolates from the outbreak in following year, were susceptible to the antiviral action of rimantadine.
在两个冬季流感暴发期间鉴定出的甲型流感病毒临床分离株，通过对先前Belshe等人（R. B. Belshe、B. Burk、F. Newman、R. L. Cerruti和I. S. Sim，《病毒学杂志》62:1508 - 1512，1988年）所述方法进行改良的酶联免疫吸附测定，检测其对金刚烷胺的敏感性。计算每种病毒的感染性滴度和金刚烷胺的50%抑制浓度。在测试的105株甲型流感病毒分离株中，1988年和1989年暴发中的28株甲型H1N1分离株以及次年暴发中的77株甲型H3N2分离株，对金刚烷胺的抗病毒作用敏感。
