Sonoguchi T, Naito H, Hara M, Takeuchi Y, Fukumi H
J Infect Dis. 1985 Jan;151(1):81-8. doi: 10.1093/infdis/151.1.81.
A total of 663 pupils at four schools were studied serologically and clinically during a period of large sequential and/or mixed epidemics of infection with two subtypes of influenza A virus, H3N2 and H1N1. Of 91 middle-school pupils infected with H3N2 virus shortly before and 82 pupils not previously infected with this subtype, 59% and 91% became infected with H1N1 virus, respectively; this difference was significant. Similar results were obtained at the two primary schools studied. At a high school where epidemics due to the H3N2 and H1N1 subtypes occurred concurrently, the rate of infection of individual pupils with both viruses (2%) was significantly lower than those at the other three schools (21%, 23%, and 31%, respectively), where an epidemic caused by the H3N2 subtype appeared first and was then partially overlapped and succeeded by an epidemic caused by the H1N1 subtype. These findings suggest the existence of cross-subtype protection in humans during sequential and/or concurrent epidemics caused by two viral subtypes.
在甲型流感病毒H3N2和H1N1两种亚型感染的大规模连续和/或混合流行期间，对四所学校的663名学生进行了血清学和临床研究。在91名不久前感染H3N2病毒的中学生和82名以前未感染该亚型的学生中，分别有59%和91%感染了H1N1病毒；这一差异具有统计学意义。在另外两所小学也得到了类似的结果。在一所同时发生H3N2和H1N1亚型流行的高中，个体学生同时感染两种病毒的比例（2%）明显低于其他三所学校（分别为21%、23%和31%），在其他三所学校中，先是出现了由H3N2亚型引起的流行，然后部分重叠并被由H1N1亚型引起的流行所取代。这些发现表明，在由两种病毒亚型引起的连续和/或同时流行期间，人类存在交叉亚型保护。
