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成人甲型流感病毒H3N2亚型感染的口服盐酸金刚乙胺治疗

Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults.

作者信息

Hayden F G, Monto A S

出版信息

Antimicrob Agents Chemother. 1986 Feb;29(2):339-41. doi: 10.1128/AAC.29.2.339.

DOI:10.1128/AAC.29.2.339
PMID:3521480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176405/
Abstract

In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic symptoms compared with placebo treatment.

摘要

在一项针对无并发症的甲型H3N2亚型流感病毒感染患者的随机双盲试验中，与安慰剂治疗相比，金刚乙胺治疗（200毫克/天，持续5天）可使鼻分泌物病毒滴度（第2至4天）、最高体温（第2和3天）、退热时间（平均缩短37小时）以及全身症状显著降低。

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本文引用的文献

1
Plaque inhibition assay for drug susceptibility testing of influenza viruses.用于流感病毒药物敏感性测试的噬斑抑制试验。
Antimicrob Agents Chemother. 1980 May;17(5):865-70. doi: 10.1128/AAC.17.5.865.
2
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection.一项关于金刚烷胺和金刚乙胺预防甲型流感感染的对照试验。
N Engl J Med. 1982 Sep 2;307(10):580-4. doi: 10.1056/NEJM198209023071002.
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Successful treatment of naturally occurring influenza A/USSR/77 H1N1.成功治疗自然发生的甲型流感/苏联/77 H1N1。
JAMA. 1981 Mar 20;245(11):1128-31. doi: 10.1001/jama.245.11.1128.
4
Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics.盐酸金刚烷胺和盐酸金刚乙胺副作用的差异与药代动力学的差异有关。
Antimicrob Agents Chemother. 1983 Mar;23(3):458-64. doi: 10.1128/AAC.23.3.458.
5
Therapeutic efficacy of amantadine HCl and rimantadine HCl in naturally occurring influenza A2 respiratory illness in man.盐酸金刚烷胺和盐酸金刚乙胺对人类自然发生的甲型流感2型呼吸道疾病的治疗效果。
N Engl J Med. 1969 Sep 11;281(11):579-84. doi: 10.1056/NEJM196909112811102.
6
Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak.流感的治疗。盐酸金刚乙胺在自然发生的甲型流感2型疫情中的治疗效果。
Am J Med Sci. 1969 May;257(5):328-35. doi: 10.1097/00000441-196905000-00005.
7
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Antimicrob Agents Chemother. 1985 Aug;28(2):216-21. doi: 10.1128/AAC.28.2.216.