Roberts D B, Evans-Roberts S M
Mol Gen Genet. 1976 Oct 18;148(1):57-64. doi: 10.1007/BF00268546.
Extracts of late larval lethal mutants were compared with extracts of wild type larvae of the same developmental age on double diffusion plates using 16 different antisera. Nearly all of the mutant extracts showed relative antigen concentration differences compared with the wild type and four of the mutants lacked a protein at death found in the wild type of the same developmental age. In each case it was a different protein. The results are discussed by considering the different ways in which mutations can lead to the loss of a protein in developing systems.
在双扩散平板上，使用16种不同的抗血清，将晚期幼虫致死突变体的提取物与相同发育年龄的野生型幼虫的提取物进行比较。与野生型相比，几乎所有突变体提取物都显示出相对抗原浓度差异，并且其中四个突变体在死亡时缺乏在相同发育年龄的野生型中发现的一种蛋白质。在每种情况下，缺失的都是不同的蛋白质。通过考虑突变导致发育系统中蛋白质缺失的不同方式来讨论这些结果。
