Hwang T I, Yang C R
Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1993 Oct;52(4):253-7.
Perycit (Pentaerythriol Tetranicotinate), a slow releasing drug, is one of the drugs used for treating hyperlipemia. Patients with erectile dysfunction (impotence) associated with hyperlipemia increasingly seek help at urological services. This study investigates the clinical effect, both objective and subjective of Perycit on anti-hyperlipemia as well as on impotence. Twenty patients with a more than one year history of impotence with hyperlipemia were enrolled in this randomized, single-blind study. Decrease of total cholesterol, and triglyceride, as well as the increase of high density lipoprotein cholesterol in the study group (Perycit, 500 mg, tid, for 3 months) were significantly different from the pre-treatment period and in the control group (Trental, 100 mg, tid, for 3 months) (p < 0.05 or p < 0.01). Moreover, improvement in sexual function was shown to be better in the study group than in either the pretreatment period and control groups, objectively and subjectively (p < 0.05 or p < 0.01). Tolerable facial flush was found in 3 of these 20 patients, but no major side effects were encountered. In conclusion, this study indicates Perycit is effective for anti-hyperlipemia as well as for aiding improvement of sexual dysfunction. Since it is a slow-releasing preparation, the side effect is minimal. It is recommended for patients with hyperlipemia alone, or those who suffer from combined erectile dysfunction.
培脂醇（季戊四醇四烟酸酯）是一种缓释药物，是用于治疗高脂血症的药物之一。患有与高脂血症相关的勃起功能障碍（阳痿）的患者越来越多地在泌尿外科寻求帮助。本研究调查了培脂醇在抗高脂血症以及阳痿方面的客观和主观临床效果。20名患有高脂血症且阳痿病史超过一年的患者参与了这项随机、单盲研究。研究组（培脂醇，500毫克，每日三次，共3个月）的总胆固醇和甘油三酯降低以及高密度脂蛋白胆固醇升高与治疗前期和对照组（曲克芦丁，100毫克，每日三次，共3个月）相比有显著差异（p<0.05或p<0.01）。此外，研究组在性功能改善方面在客观和主观上均显示优于治疗前期和对照组（p<0.05或p<0.01）。这20名患者中有3名出现了可耐受的面部潮红，但未遇到重大副作用。总之，本研究表明培脂醇在抗高脂血症以及帮助改善性功能方面是有效的。由于它是一种缓释制剂，副作用最小。推荐给单纯高脂血症患者或患有合并勃起功能障碍的患者。
