Stobiecki M, Blaszczyk B, Kowalczyk-Bronisz S H, Gulewicz K
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań.
J Appl Toxicol. 1993 Sep-Oct;13(5):347-52. doi: 10.1002/jat.2550130509.
Seed extracts obtained from Lupinus albus and Lupinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weight basis) and were non-toxic. Their acute toxicity (LD50) in the mouse is > 4000 mg kg-1 body wt. After fractionation, the extract from L. angustifolius seeds afforded several fractions with differing toxicities (LD50 750-4000 mg kg-1 body wt.). None of the fractions tested in vitro were toxic. The results obtained showed that, in spite of the alkaloids, other low-molecular-weight constituents present significantly modified the toxicity of the lupin extracts.
用48%乙醇处理从白羽扇豆和窄叶羽扇豆中获得的种子提取物，其生物碱含量约为10%（以干重计），且无毒。它们对小鼠的急性毒性（半数致死量）>4000毫克/千克体重。分级分离后，窄叶羽扇豆种子提取物得到了几种毒性不同的级分（半数致死量为750 - 4000毫克/千克体重）。体外测试的所有级分均无毒。所得结果表明，尽管存在生物碱，但其他低分子量成分显著改变了羽扇豆提取物的毒性。
