Tode T, Kikuchi Y, Hirata J, Kita T, Imaizumi E, Nagata I
Department of Obstetrics and Gynecology, National Defense Medical College, Saitama.
Nihon Sanka Fujinka Gakkai Zasshi. 1993 Nov;45(11):1275-82.
We examined the inhibitory effect of the oral administration of ginsenoside Rh2 (Rh2) on tumor growth in nude mice bearing human ovarian cancer cells (HRA). In the first experiment, it was revealed that daily administration of 30 microM Rh2 significantly inhibited tumor growth. In the second experiment, therefore, various concentration of Rh2 (1, 15, 30, 60, 120 microM) were administered every day for 91 days, beginning the day after tumor inoculation. Treatment with Rh2 resulted in a remarkable retardation of the HRA cell tumor growth. In particular, tumor growth in mice treated with 15, 30 and 120 microM Rh2 was significantly inhibited, compared to that in CDDP treated mice as well as in untreated mice. Consequently, 50% survival in nude mice treated with 15, 30 and 120 microM Rh2 was significantly prolonged, compared to that not only in untreated mice but also in CDDP treated mice. No side effect was observed in any mice treated with Rh2. Red ginseng containing Rh2 has been used exclusively, orally administered. In the present study, we considered that oral administration of Rh2, which is a component of red ginseng, has strong inhibitory effects on human ovarian cancer cell growth in nude mice.
我们研究了口服人参皂苷Rh2（Rh2）对荷人卵巢癌细胞（HRA）裸鼠肿瘤生长的抑制作用。在第一个实验中，结果显示每天给予30微摩尔Rh2可显著抑制肿瘤生长。因此，在第二个实验中，从接种肿瘤后的第二天开始，每天给予不同浓度的Rh2（1、15、30、60、120微摩尔），持续91天。Rh2治疗导致HRA细胞肿瘤生长明显迟缓。特别是，与顺铂治疗的小鼠以及未治疗的小鼠相比，用15、30和120微摩尔Rh2治疗的小鼠肿瘤生长受到显著抑制。因此，与未治疗的小鼠以及顺铂治疗的小鼠相比，用15、30和120微摩尔Rh2治疗的裸鼠50%生存率显著延长。在用Rh2治疗的任何小鼠中均未观察到副作用。仅使用了含Rh2的红参进行口服给药。在本研究中，我们认为口服作为红参成分之一的Rh2对裸鼠人卵巢癌细胞生长具有强大的抑制作用。
