Menard O, Dousset B, Jacob C, Martinet Y
Service de Pneumologie, Hôpital de Brabois, Vandoeuvre-les-Nancy, France.
Eur J Cancer. 1993;29A(13):1806-9. doi: 10.1016/0959-8049(93)90525-k.
Carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) level determinations were carried out by radioimmunoassay in pleural fluid and plasma samples obtained from 24 patients with malignant pleural effusions and 18 patients with non-malignant pleural effusions, and compared to cytological and pathological results. Using a pathological cut-off level of 25 ng/ml for CEA and 8 ng/ml for NSE, we demonstrated that, in the diagnosis of the malignant nature of pleural effusions, the simultaneous quantification of CEA and NSE in pleural fluid possesses better discriminative values than the simultaneous quantification of both markers in plasma or the separate quantification of each marker, in pleural fluid and in plasma.
采用放射免疫分析法对24例恶性胸腔积液患者和18例非恶性胸腔积液患者的胸水及血浆样本进行癌胚抗原（CEA）和神经元特异性烯醇化酶（NSE）水平测定，并与细胞学和病理结果进行比较。以CEA病理临界值25 ng/ml和NSE病理临界值8 ng/ml为标准，我们发现，在诊断胸腔积液的恶性性质时，胸水同时定量检测CEA和NSE比血浆同时定量检测这两种标志物或胸水及血浆分别定量检测单一标志物具有更好的鉴别价值。
