Battistini N, Virgili F, Bedogni G, Gambella G R, Bini A
Institute of Human Physiology and Pathology, University of Modena, Italy.
Br J Nutr. 1993 Sep;70(2):433-8. doi: 10.1079/bjn19930137.
Total body electrical conductivity (TOBEC) is a simple and non-invasive method for the assessment of body composition in vivo. Information regarding the applicability of TOBEC in the condition of abnormal fluid balance is scarce. In the present paper we give the results of the comparison between TOBEC and total body water (TBW; assessed by the tritium dilution technique) in three groups of animals: (1) healthy (n 17), (2) expanded fluid volume by secondary biliary cirrhosis (SBC; n 9) and (3) Furosemide-treated rats (n 9). The TOBEC score and TBW by tritium dilution were found to be highly correlated in the pooled sample (r 0.90) and in normal (r 0.87), SBC (r 0.73) and Furosemide-treated (r 0.89) rats. However, the relationship between TOBEC and TBW, described by least-squares regression analysis, was found to be similar for SBC and normal rats but was significantly different for Furosemide-treated and normal rats. These findings suggest that TOBEC is unable to track TBW accurately when the ratio between intracellular and extracellular water is chronically or acutely altered.
总体电导率（TOBEC）是一种用于体内评估身体成分的简单且非侵入性的方法。关于TOBEC在异常液体平衡情况下适用性的信息很少。在本文中，我们给出了三组动物中TOBEC与总体水（TBW；通过氚稀释技术评估）比较的结果：（1）健康组（n = 17），（2）继发性胆汁性肝硬化（SBC）导致液体量增加组（n = 9），以及（3）呋塞米治疗的大鼠组（n = 9）。发现在合并样本（r = 0.90）以及正常大鼠（r = 0.87）、SBC大鼠（r = 0.73）和呋塞米治疗的大鼠（r = 0.89）中，TOBEC评分与通过氚稀释测得的TBW高度相关。然而，通过最小二乘回归分析描述的TOBEC与TBW之间的关系，在SBC大鼠和正常大鼠中相似，但在呋塞米治疗的大鼠和正常大鼠中存在显著差异。这些发现表明，当细胞内和细胞外水的比例长期或急性改变时，TOBEC无法准确追踪TBW。
